产品名称

英文名称：Afatinib

同义词

BIBW2992、(2E)-N-(4-(3-chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-enamide、AFATINIB [MI]、AKOS001015518、BIBW2992 - Afatinib、NSC799327、NSC-799327、850140-72-6 (free base)、Afatinib [USANINN]、EX-A065、(S,E)-N-(4-((、阿法替尼

产品性质

CAS编号：439081-18-2

分子式：C24H25ClFN5O3

分子量：485.94

PubChem编号：10184653

别名：阿法替尼

英文别名：BIBW2992|(2E)-N-(4-(3-chloro-4-fluoroanilino)-7-(((3S)-oxolan-3-yl)oxy)quinoxazolin-6-yl)-4-(dimethylamino)but-2-enamide|AFATINIB [MI]|AKOS001015518|BIBW2992 - Afatinib|NSC799327|NSC-799327|850140-72-6 (free base)|Afatinib [USANINN]|EX-A065|(S,E)-N-(4-((

规格或纯度：95%

英文名称：Afatinib

生化机理：强力，不可逆的Her2 / ErbB 2和EGFR激酶抑制剂（EGFR（wt），EGFR（L858R），EGFR（L858R / T790M）和HER2的IC 50值分别为0.5、0.4、10和14 nM。在体内显示抗肿瘤作用。口服具有活性

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg卖完停产，不再备货；如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：Afatinib (BIBW2992) is an irreversible EGFR/Neu inhibitor with an IC50 of 14 nM. Afatinib is a potent inhibitor of EGFR phosphorylation. Afatinib showed positive results in assays against a variety of human cancer cell lines, including A431, murine NIH-3T3 cells, and breast cancer cell line BT-474.An irreversible and potent EGFR/Neu inhibitor, inhibits EGFR phosphorylationAfatinib (BIBW2992) is an irreversible EGFR/Neu inhibitor with an IC50 of 14 nM. Afatinib is a potent inhibitor of EGFR phosphorylation. Afatinib showed positive results in assays against a variety of human cancer cell lines, including A431, murine NIH-3T3 cells, and breast cancer cell line BT-474.An irreversible and potent EGFR/Neu inhibitor, inhibits EGFR phosphorylation

IUPAC Name：(E)-N-[4-(3-chloro-4-fluoroanilino)-7-[(3S)-oxolan-3-yl]oxyquinazolin-6-yl]-4-(dimethylamino)but-2-enamide

INCHI：InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m0/s1

InChi Key：ULXXDDBFHOBEHA-CWDCEQMOSA-N

Canonical SMILES：CN(C)CC=CC(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)OC4CCOC4

Isomeric SMILES：CN(C)C/C=C/C(=O)NC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=C(C=C3)F)Cl)O[C@H]4CCOC4

PubChem CID：10184653

溶解性：DMSO 97 mg/mL Water <1 mg/mL Ethanol 15 mg/mL

象形图：

信号词：Danger

危险声明：H319 Causes serious eye irritationH301 Toxic if swallowedH410 Very toxic to aquatic life with long lasting effectsH372 Causes damage to organs through prolonged or repeated exposureH361 Suspected of damaging fertility or the unborn childH362 May cause harm to breast-fed children

预防措施声明：P305+P351+P338,P273,P280,P321,P405,P501,P264,P260,P270,P391,P330,P263,P203,P264+P265,P301+P316,P318,P337+P317,P319

产品包装