产品名称

英文名称：Lenvatinib (E7080)

同义词

Lenvatinib、417716-92-8、E7080、4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide、E7080 (Lenvatinib)、Lenvatinib (E7080)、E-7080、ER-203492-00、E 7080、Lenvatinib free base、Kisplyx、UNII-EE083865G2、4-{3-Chloro-4-[(Cyclopropylcarbamoyl)am、乐伐替尼、仑伐替尼、乐法替尼

产品性质

CAS编号：417716-92-8

分子式：C21H19ClN4O4

分子量：426.85

PubChem编号：9823820

别名：乐伐替尼|仑伐替尼|乐法替尼

英文别名：Lenvatinib|417716-92-8|E7080|4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxamide|E7080 (Lenvatinib)|Lenvatinib (E7080)|E-7080|ER-203492-00|E 7080|Lenvatinib free base|Kisplyx|UNII-EE083865G2|4-{3-Chloro-4-[(Cyclopropylcarbamoyl)am

规格或纯度：≥99%

英文名称：Lenvatinib (E7080)

储存温度：-20°C储存

运输条件：超低温冰袋运输

备注：5mg、10mg、100mg卖完停产，不再备货

产品介绍：Lenvatinib (E7080)是一种多靶点抑制剂，作用于VEGFR2(KDR)/VEGFR3(Flt-4)最有效，IC50为4 nM/5.2，对VEGFR1/Flt-1作用效果稍弱，作用于VEGFR2/3比作用于FGFR1， PDGFRα/β选择性高10倍左右。Phase 3。Lenvatinib is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.Lenvatinib (E7080) is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β. Phase 3.Lenvatinib is an orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.

PubChem SID：488196334

PubChem SID url：https//pubchem.ncbi.nlm.nih.gov/substance/488196334

IUPAC Name：4-[3-chloro-4-(cyclopropylcarbamoylamino)phenoxy]-7-methoxyquinoline-6-carboxamide

INCHI：InChI=1S/C21H19ClN4O4/c1-29-19-10-17-13(9-14(19)20(23)27)18(6-7-24-17)30-12-4-5-16(15(22)8-12)26-21(28)25-11-2-3-11/h4-11H,2-3H2,1H3,(H2,23,27)(H2,25,26,28)

InChi Key：WOSKHXYHFSIKNG-UHFFFAOYSA-N

Canonical SMILES：COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl

Isomeric SMILES：COC1=CC2=NC=CC(=C2C=C1C(=O)N)OC3=CC(=C(C=C3)NC(=O)NC4CC4)Cl

关联CAS：417716-92-8

PubChem CID：9823820

MeSH Entry Terms：4-(3-chloro-4-(((cyclopropylamino)carbonyl)amino)phenoxy)-7-hydroxy-6-quinolinecarboxamide;4-(3-chloro-4-((cyclopropylaminocarbonyl)amino)phenoxy)-7-methoxy-6-quinolinecarboxamide;4-(3-chloro-4-(N'-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxami

ChEMBL Ligand：CHEMBL1289601

Wikipedia：Lenvatinib

CAS Registry No.：417716-92-8

RCSB PDB Ligand：LEV

PEP：lenvatinib

Reactome Reaction：R-HSA-2077420, R-HSA-9669854, R-HSA-9669900, R-HSA-9674430, R-HSA-9674095, R-HSA-2077424

Reactome Drug：R-ALL-2023393

DrugCentral Ligand：4942

溶解性：DMSO 40 mg/mL (93.7 mM); Water <1 mg/mL (<1 mM); Ethanol <1 mg/mL (<1 mM)

产品包装