产品名称

英文名称：Fosbretabulin disodium

同义词

Fosbretabulin disodium、168555-66-6、CA4DP、Combretastatin A4 disodium phosphate、CA 4P、combretastatin A4 phosphate、Zybrestat、Fosbretabulin disodium [USAN]、Fosbretabulin (disodium)、Combretastatin A4 Phosphate Disodium Salt、CA-4DP、Fosbretabulin Disodium Salt、F、考布他丁 A-4 磷酸二钠盐

产品性质

CAS编号：168555-66-6

分子式：C18H19O8P·2Na

分子量：440.29

MDL号：MFCD00943911

PubChem编号：6918309

别名：考布他丁 A-4 磷酸二钠盐

英文别名：Fosbretabulin disodium|168555-66-6|CA4DP|Combretastatin A4 disodium phosphate|CA 4P|combretastatin A4 phosphate|Zybrestat|Fosbretabulin disodium [USAN]|Fosbretabulin (disodium)|Combretastatin A4 Phosphate Disodium Salt|CA-4DP|Fosbretabulin Disodium Salt|F

规格或纯度：≥99%

英文名称：Fosbretabulin disodium

生化机理：Combretastatin A4 Phosphate Disodium Salt is the salt form of Combretastatin A4, a phosphorylated microtubule depolymerizing molecule which induces tumor necrosis by regression of unstable nascent tumor neo-vessels. Studies sμggest that Combretastatin A4 Phosphate Disodium Salt selectively inhibits endothelial tumor cells via disrupting VE-cadherin (vascular endothelial-cadherin). In addition, Combretastatin A4 Phosphate Disodium Salt can increase the permeability of endothelial cells while inhibiting their migration and suppress capillary tube formation via disruption of VE-cadherin. Furthermore, Combretastatin A4 Phosphate Disodium Salt can change the morphology of endothelial cells by altering their tubulin cytoskeleton.Vascular-disrupting and antineoplastic combretastatin prodrug. Microtubule destabilizing agent. Anticancer potential. Active in vitro and in vivo .

储存温度：2-8°C储存

运输条件：冰袋运输

备注：如果有可能，您尽量在使用的当天配置溶液，并在当天使用完它。但是，如果您需要预先配制储备溶液，我们建议您将溶液等份保存在-20°C的密封小瓶中。通常，它们最多可以使用一个月。在使用前和打开样品瓶之前，我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度，用法和处理的建议吗？请访问我们的常见问题（FAQ）页面以获取更多详细信息。

产品介绍：A microtubule depolymerizing molecule.A microtubule depolymerizing molecule.

IUPAC Name：disodium;[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate

INCHI：InChI=1S/C18H21O8P.2Na/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3;;/h5-11H,1-4H3,(H2,19,20,21);;/q;2*+1/p-2/b6-5-;;

InChi Key：VXNQMUVMEIGUJW-XNOMRPDFSA-L

Canonical SMILES：COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+]

Isomeric SMILES：COC1=C(C=C(C=C1)/C=C\C2=CC(=C(C(=C2)OC)OC)OC)OP(=O)([O-])[O-].[Na+].[Na+]

WGK Germany：3

PubChem CID：6918309

溶解性：DMSO Water 28 mg/mL Ethanol

敏感性：对热敏感

产品包装