产品详情
产品名称 英文名称:Suramin hexasodium salt 同义词 SURAMIN SODIUM [WHO-DD]、EINECS 204-949-3、Nagananinum、Bayer 205 (TN)、Suramine sodique、AS-81747、Suramine sodique [INN-French]、BAY-205、Suramin. Hexasodium Salt、NCGC00094436-02、Suramin (sodium salt)、M02480、hexasodium;8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,、苏拉明钠 产品性质 CAS编号:129-46-4 分子式:C51H34N6Na6O23S6 分子量:1429.17 Beilstein号:3694087 EC号:204-949-3 MDL号:MFCD00210217 PubChem编号:8514 别名:苏拉明钠 英文别名:SURAMIN SODIUM [WHO-DD]|EINECS 204-949-3|Nagananinum|Bayer 205 (TN)|Suramine sodique|AS-81747|Suramine sodique [INN-French]|BAY-205|Suramin. Hexasodium Salt|NCGC00094436-02|Suramin (sodium salt)|M02480|hexasodium;8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6, 规格或纯度:≥98% 英文名称:Suramin hexasodium salt 生化机理:Suramin is a polysulfonated naphthylurea anticancer agent that inhibits tumor cell proliferation. It inhibits the activity of topoisomerase II by blocking the binding of the enzyme to DNA. It′s antiangiogenic activity may be related to its ability to bind to and inhibit the activity of several growth factors, including FGFa, FGFb, and PGDF. It uncouples G-proteins from receptors. It is an broad spectrum antagonist at P2X and P2Y purinergic receptors. Suramin has well documented antiprotozoal and anthelmintic activity.Non-selective P2 purinergic antagonist (pEC 50 values are 4.5 (P2X 2 ), 5.4 (P2X 5 ), 4.3 (P2Y 2 ), 4.0 (P2Y 4 ) and 4.8 (P2Y 11 )). Displays diverse biological actions. Shows antitumor activity, inhibits binding of multiple growth factors and additionall 储存温度:2-8°C储存 运输条件:冰袋运输 备注:如果有可能,您尽量在使用的当天配置溶液,并在当天使用完它。但是,如果您需要预先配制储备溶液,我们建议您将溶液等份保存在-20°C的密封小瓶中。通常,它们最多可以使用一个月。在使用前和打开样品瓶之前,我们建议您让您的产品在室温下平衡至少1小时。需要更多关于溶解度,用法和处理的建议吗?请访问我们的常见问题(FAQ)页面以获取更多详细信息。 产品介绍:Suramin sodium salt has been usedas apotent blocker of rat P2Y2 purinergic receptorto study its effects on short circuit current (Isc) across strial marginal cellsto show its effects on initial burst of glial activityto assess its neuroprotective potential in ratsas apurinoceptor inhibitor, to explore the mechanism of action of extracellular adenosine triphosphate (eATP) IUPAC Name:hexasodium;8-[[4-methyl-3-[[3-[[3-[[2-methyl-5-[(4,6,8-trisulfonatonaphthalen-1-yl)carbamoyl]phenyl]carbamoyl]phenyl]carbamoylamino]benzoyl]amino]benzoyl]amino]naphthalene-1,3,5-trisulfonate INCHI:InChI=1S/C51H40N6O23S6.6Na/c1-25-9-11-29(49(60)54-37-13-15-41(83(69,70)71)35-21-33(81(63,64)65)23-43(45(35)37)85(75,76)77)19-39(25)56-47(58)27-5-3-7-31(17-27)52-51(62)53-32-8-4-6-28(18-32)48(59)57-40-20-30(12-10-26(40)2)50(61)55-38-14-16-42(84(72,73)74)36-22-34(82(66,67)68)24-44(46(36)38)86(78,79)80;;;;;;/h3-24H,1-2H3,(H,54,60)(H,55,61)(H,56,58)(H,57,59)(H2,52,53,62)(H,63,64,65)(H,66,67,68)(H,69,70,71)(H,72,73,74)(H,75,76,77)(H,78,79,80);;;;;;/q;6*+1/p-6 InChi Key:VAPNKLKDKUDFHK-UHFFFAOYSA-H Canonical SMILES:CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] Isomeric SMILES:CC1=C(C=C(C=C1)C(=O)NC2=C3C(=CC(=CC3=C(C=C2)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])NC(=O)C4=CC(=CC=C4)NC(=O)NC5=CC=CC(=C5)C(=O)NC6=C(C=CC(=C6)C(=O)NC7=C8C(=CC(=CC8=C(C=C7)S(=O)(=O)[O-])S(=O)(=O)[O-])S(=O)(=O)[O-])C.[Na+].[Na+].[Na+].[Na+].[Na+].[Na+] PubChem CID:8514 溶解性:Soluble in water (50 mg/mL), 95% ethanol, and DMSO (10 mM). Insoluble in benzene, ether, and chloroform. 敏感性:对热敏感 象形图: 信号词:Warning 危险声明:H317 May cause an allergic skin reaction 预防措施声明:P261,P280,P302+P352,P321,P501,P272,P333+P313,P362+P364 产品包装
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