产品名称

英文名称：TAK-875

同义词

Fasiglifam、TAK-875、1000413-72-8、TAK875、TAK 875、(S)-2-(6-((2',6'-Dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid、Tak-875 anhydrous、GLP1W4JXAH、TAK-875(Fasiglifam)、3-Benzofuranacetic acid, 6-[[2',6

产品性质

CAS编号：1000413-72-8

分子式：C29H32O7S

分子量：524.64

PubChem编号：24857286

英文别名：Fasiglifam|TAK-875|1000413-72-8|TAK875|TAK 875|(S)-2-(6-((2',6'-Dimethyl-4'-(3-(methylsulfonyl)propoxy)-[1,1'-biphenyl]-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid|Tak-875 anhydrous|GLP1W4JXAH|TAK-875(Fasiglifam)|3-Benzofuranacetic acid, 6-[[2',6

规格或纯度：≥98%

英文名称：TAK-875

生化机理：TAK-876 is a selective G protein-coupled receptor 40 (GPR40) agonist that has been developed to improve the secretion of insulin in a glucose-dependent manner.

储存温度：-20°C储存

运输条件：超低温冰袋运输

产品介绍：Fasiglifam (TAK-875)是一种选择性GPR40激动剂，在表达人GPR40的CHO细胞系中EC50为14 nM，比油酸有效400倍。TAK-875 is a potent, selective and orally bioavailable GPR40 agonist with EC50 of 0.072 μM.A selective G protein-coupled receptor 40 (GPR40) agonist.

ALogP：4.7

IUPAC Name：2-[(3S)-6-[[3-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]acetic acid

INCHI：InChI=1S/C29H32O7S/c1-19-12-25(34-10-5-11-37(3,32)33)13-20(2)29(19)22-7-4-6-21(14-22)17-35-24-8-9-26-23(15-28(30)31)18-36-27(26)16-24/h4,6-9,12-14,16,23H,5,10-11,15,17-18H2,1-3H3,(H,30,31)/t23-/m1/s1

InChi Key：BZCALJIHZVNMGJ-HSZRJFAPSA-N

Canonical SMILES：CC1=CC(=CC(=C1C2=CC=CC(=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCCCS(=O)(=O)C

Isomeric SMILES：CC1=CC(=CC(=C1C2=CC=CC(=C2)COC3=CC4=C(C=C3)[C@@H](CO4)CC(=O)O)C)OCCCS(=O)(=O)C

PubChem CID：24857286

CAS Registry No.：1000413-72-8

ChEMBL Ligand：CHEMBL1829174

RCSB PDB Ligand：2YB

GPCRdb Ligand：fasiglifam

溶解性：DMSO ≥100mg/mL Water <1.2mg/mL Ethanol ≥10mg/mL

熔点：123-127°C

产品包装