3-甲基-1-苯基-2-吡唑啉-5-酮

别名

MCI-186 - CAS 89-25-8 - Calbiochem,3-Methyl-1-phenyl-2-pyrazolin-5-one, PMP, Edaravone

一般描述

A free radical scavenger and antioxidant that reduces post-ischemic brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 μM). Inhibits mitochondrial permeability transition pore. A free radical scavenger and antioxidant that reduces post-ischemie brain injury. Inhibits iron-dependent peroxidation in rat brain homogenates (IC50 = 15 μM). Inhibits mitochondrial permeability transition pore.

生化/生理作用

Cell permeable: no Primary Target
A free radical scavenger and antioxidant Product does not compete with ATP. Reversible: no Target IC50: 15 μM inhibiting iron-dependent peroxidation in rat brain homogenates

重悬

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他说明

Katare, R. G., et al. 2003. Am. J. Physiol.285, H2171.
Kawai, H., et al. 1997. J. Pharmacol. Exp. Ther. 281, 921.
Yamamoto, Y., et al. 1996. Redox. Report 2, 333.
Watanabe, T., et al. 1994. J. Pharmacol. Exp. Ther. 268, 1597.
Nishi, H., et al. 1989. Stroke 20, 1236.